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Amphotericin B trihydrate

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Formula: C47H73NO17
CAS: 1397-89-3

Identification

Structural Formula
Amphotericin B trihydrate
CAS:
1397-89-3
EINECS:
215-742-2
Molecular Formula:
C47H73NO17
MDL:
MFCD00877763
SMILES:
CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
Synonym:
lns-amb ; halizon ; fungizone ; ns718 ; abelcet ; fungilin ; ambisome ; amphocin ; amphozone ; abelecet


Description

Amphotericin B trihydrate is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. Its mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B trihydrate's antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D sensitivity in drug resistant HELA cells in vitro.


Suppliers

Santa Cruz Biotechnology, Inc.
227265
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Prices & Availability




Data is processed


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Properties for Amphotericin B trihydrate

Molecular Weight:
924.08 g·mol−1
Density:
1.34
Melting point:
>170 °C
Boiling point:
~1140.4° C at 760 mmHg (Predicted)
Solubility:
sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at -20?#x00b0;C. Stable at 37?#x00b0;C for 3 days.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R40 - Limited evidence of a carcinogenic effect
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
C, Xi, Xn, T
Hazard symbol T Hazard symbol C Hazard symbol Xn Hazard symbol Xi
Storage temperature :
2-8°C
RID/ADR certification :
UN 1759 8 / PG 3
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Alternative Distributors of [Amphotericin B trihydrate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Advance Scientific & Chemical, Inc. | Inter-Chemical Ltd. | World Biopharma Group Limited / World (Jiangsu) Industry Co.,Ltd | Chemwerth Inc. | Molekula GmbH | Chem-Impex International, Inc. | Hallochem Pharma Co., Ltd. | 3B Scientific Corporation | World Industry Co. Ltd., (Factory) | Taizhou Huading Chemical Co., Ltd. | Discovery Fine Chemicals Limited | Chengdu Qiaofeng Technological Development Co., Ltd. | Nantong Wanrong International Trading Co., Ltd. | Atomole Scientific Co., Ltd. | TCS INDUSTRY LTD. | Lanospharma Laboratories Co., Ltd. | Keen Union International Limited | Jinan Great Chemical Co., Ltd. | Carl Roth GmbH + Co KG | Bichem Lab Co., Ltd. | Suzhou Sibian Chemical Technology Co., Ltd. | API Vanguard | Pharmfar Co., Ltd. | BOC Sciences | Jinan Haohua Industry Co., Ltd. | Skyrun Industrial Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Clearsynth Canada INC. | scienTEST | Haihang Industry Co., Ltd.

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