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ATM Kinase Inhibitor

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Formula: C21H17NO3S2
CAS: 587871-26-9
search Element: inhibitor kinase

Identification

Structural Formula
ATM Kinase Inhibitor
CAS:
587871-26-9
EINECS:
Molecular Formula:
C21H17NO3S2
MDL:
MFCD08276985
SMILES:
C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
Synonym:
4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)- ; 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one ; KU-55933 ;


Description

ATM Kinase Inhibitor (KU 55933) is a cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated), a serine/threonine protein kinase, that exhibits an IC50 of 13 nmol/L and a Ki of 2.2 nmol/L. ATM is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells and signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NALP2 (NBS1), and BRCA1. Investigators discovered that this product shows inhibition specificity for other phosphatidylinositol 3'-kinase-like kinases as well. Research shows that HIV-1 integrase stimulates ATM-dependent DNA damage response and that this inhibitor is capable of suppressing the replication of both wild-type and drug-resistant HIV-1. Studies also reveal two novel ATM functions: regulation of ribonucleotide reductase and mitochondrial homeostasis. Additional research shows that ATM Kinase Inhibitor and ATM/ATR Kinase Inhibitor induces senescent breast, lung, and colon carcinoma cells to undergo cell death which is directly effected by p21. ATM Kinase Inhibitor is an inhibitor of Atm.


Suppliers

Aea.ltd
A420840
Santa Cruz Biotechnology, Inc.
202963
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2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one
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Prices & Availability




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Properties for ATM Kinase Inhibitor

Molecular Weight:
395.49 g·mol−1
Density:
1.419 g/cm3
Melting point:
229.98° C (Predicted)
Boiling point:
628 °C at 760 mmHg
Flash point:
333.6 °C
Solubility:
Soluble in DMSO (50 mg/ml at 25° C), ethanol (50 mM), and water (<1 mg/ml at 25° C).
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Alternative Distributors of [ATM Kinase Inhibitor]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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