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1-β-D-Arabinofuranosylcytosine

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Formula: C9H13N3O5
CAS: 147-94-4

Identification

Structural Formula
1-β-D-Arabinofuranosylcytosine
CAS:
147-94-4
EINECS:
205-705-9
Molecular Formula:
C9H13N3O5
MDL:
MFCD00066487
SMILES:
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@H](O)C1O
Synonym:
udicil ; ara-c ; citozar ; arabitin ; aracytin ; cytosar ; arafcyt ; erpalfa ; iretin ; nsc63878


Description

1-β-D-Arabinofuranosylcytosine, a cytosine analogue, inhibits DNA polymerases α, δ, and ε, and RNA polymerases resulting in suppression of DNA synthesis and repair. 1-β-D-Arabinofuranosylcytosine acts as an antimetabolic agent which is responsible for damaging DNA during the S-phase of the cell cycle. In addition, 1-β-D-Arabinofuranosylcytosine inhibits nucleotide reductase enzymes that are needed for DNA synthesis to occur. Alternate studies suggest that 1-β-D-Arabinofuranosylcytosine is clastogenic to both spermatogonial cells and bone marrow. Furthermore, 1-β-D-Arabinofuranosylcytosine can be used to control the proliferation of glial cells.


Suppliers

Santa Cruz Biotechnology, Inc.
201628
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Prices & Availability




Data is processed


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Properties for 1-β-D-Arabinofuranosylcytosine

Molecular Weight:
243.22 g·mol−1
Density:
1.89 g/cm3 (Predicted)
Melting point:
214 °C
Boiling point:
545.68° C at 760 mmHg (Predicted)
Solubility:
H2O: 50 mg/mL, clear, colorless
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R43 - May cause sensitisation by skin contact
R63 - Possible risk of harm to the unborn child
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S37/39 - Wear suitable gloves and eye/face protection
Hazard Symbols:
Xn, Xi
Hazard symbol Xn Hazard symbol Xi
Storage temperature :
2-8°C
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Alternative Distributors of [1-β-D-Arabinofuranosylcytosine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Inter-Chemical Ltd. | Zhengzhou Chemprize Biotech Co., Ltd. | HuaiBei SanHe Developing Co., Ltd. | Hallochem Pharma Co., Ltd. | Xiang Ding Chemical International Co., Ltd | Nantong Chem-Tech. (Group) Co., Ltd. | TCI Europe NV | Matrix Scientific | Synfine Research Inc. | CCS. CHEM. Co., Ltd. | Shanghai AOKChem Group Limited | Nucleo Chemistry Co., Limited | Share Chemical Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Marketing Center of Yangzhou Princechem Co., Ltd. | Hangzhou Pharma & Chem Co. Ltd. | Lanospharma Laboratories Co., Ltd. | Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Taizhou Creating Chemical Co., Ltd. | King Tang Chemical Group Industry Co., Ltd. | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Watson International Ltd | Beijing Yangguang Furuide Chemical Co., Ltd. | Sunbow Biotech Ltd. | Jinan Haohua Industry Co., Ltd. | Finetech Industry Limited | Suzhou Vosun Chemical Co.,Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Sino Rarechem Labs Co. Ltd. | Gihi Chemicals Co., Limited | Clearsynth Canada INC. | Yangzhou Princechem Co., Ltd.

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