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Ketoconazole

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Formula: C26H28Cl2N4O4
CAS: 65277-42-1
search Element: ketoconazole

Identification

Structural Formula
Ketoconazole
CAS:
65277-42-1
EINECS:
265-667-4
Molecular Formula:
C26H28Cl2N4O4
MDL:
MFCD00058579
SMILES:
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
Synonym:
onofin k ; nizral ; fungoral ; nizoral ; fungarest ; kw-1414 ; brizoral ; r-41400 ; fitonal ; ketoderm


Description

Ketoconazole is an imidazole-containing small molecule inhibitor of cytochrome P-450-dependent steps in the biosynthesis of steroid hormones; also inhibits TXA Synthase (thromboxane synthetase) and 5-LO (5-lipoxygenase) activity. Ketoconazole exhibits antimetastatic, antineoplastic, and antipsoriatic activity. Inhibition of 5-LO (5-lipoxygenase) by Ketoconazole interrupts arachidonic acid-derived leukotriene production, which was correlated to a suppression of leukotriene-mediated anaphylactic bronchoconstriction in guinea pigs. Ketoconazole is described as reducing platelet cellular levels of thromboxane A2, suppressing thromboxane A2-mediated increase of microvascular permeability in response to ischemia insults. Ketoconazole produces an antiandrogen effect through inhibition of adrenocorticoid biosynthesis, suppressing the adrenal secretion of androgens and attenuating cortisol response. Ketoconazole is an inhibitor of CYP17A1, CYP3A4 and CYP3A5.


Suppliers

Ambeed, Inc.
A183059
H&Z Industry Co.,Ltd
HIC240960
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI8283312
Shandong Minglang Chemical Co., Ltd
SMC4201680
Autech Industry Co.,Limited
AIC3241296
R&D Scientific Inc.
RS228684
Shandong SanYoung Industry Co., Ltd
SSI4201680
Chemlyte Solutions
CS216648
Gyma Laboratories Of America, Inc.
GLOA4082040
Fabrichem, Inc.
F180360
CellMark AB
CA132396
AXO Industry SA
AIS180720
X´ian Taicheng Chem Co., Ltd
XTC3481392
Caesar & Loretz GmbH
CL240720
Sancai Industry Co.,Ltd.
SIC2881152
Aecochem Corp.
AC168504
CSNpharm, Inc.
CSN16776
Hangzhou Keying Chem Co., Ltd.
HKC3601440
Wanko Chemical Co., Ltd.
WC288864
Sigma-Aldrich International GmbH
SI3841152
scienTEST - bioKEMIX GmbH
S-B3001200
Finetech Industry Limited
FIL3001200
Carbone Scientific Co., Ltd.
CS3361008
Hefei Hirisun Pharmatech Co., Ltd
HR010485
AK Scientific, Inc.
AS228684
Simagchem Corporation
SC252756
Xingrui Industry Co., Limited
XIL3481392
BOC Sciences
BS144432
Leap Chem Co., Ltd
LC216648
Santa Cruz Biotechnology, Inc.
200496
Dayang Chem (Hangzhou) Co.,Ltd.
DC3721488
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CAS equal suppliers

Ketoconazole, 98%
Alfa (A Johnson Matthey Company)
A5441632
Ketoconazole, Pharma
Xiamen Equation Chemical Co.,Ltd
XECC12806400
cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H)-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
Chemos GmbH & Co. KG
CC38760116280
(+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
Manchester Organics Limited
P25350
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolane-4-yl]methoxyl]phenyl]piperazine
BLD Pharmatech Ltd
BP33408100224

Prices & Availability




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Properties for Ketoconazole

Molecular Weight:
531.43 g·mol−1
Density:
~1.4 g/cm3 (Predicted)
Melting point:
146°C
Boiling point:
~753.4° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (20 mg/mL warm), ethanol (20 mg/mL warm), chloroform, water (<1 mg/mL), and methanol.
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2
GHS09

GHS09
Environmental hazard
  • Acute hazards to the aquatic environment, category 1
  • Chronic hazards to the aquatic environment, categories 1, 2
  • Environmental toxicity, categories 1, 2

Safety & Transport Information

Risk Codes:
R11 - Highly flammable
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
R48/22 - Harmful: danger of serious damage to health by prolonged exposure if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R60 - May impair fertility
Safety Codes:
S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
S7 - Keep container tightly closed
Hazard Classes:
6.1(b)
Hazard Symbols:
T, N, F
Hazard symbol T Hazard symbol N Hazard symbol F
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 3
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Alternative Distributors of [Ketoconazole]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Santec Chemicals Corp. | Ningbo Zhengrun Chemicals Co., Ltd. Exp. Dept. | Hallochem Pharma Co., Ltd. | Argosi International Co., Ltd. | 3B Scientific Corporation | Shanghai Eagle Chemical Co., Ltd. | Hangzhou Think Chemical Co., Ltd. | Molekula GmbH | Hangzhou Cowin Pharma Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | East Chemical Industry Co., Ltd. | TCI Europe NV | Golden Harvest Fine Chemical Co., Ltd. | Changzhou An-Yuan Imp. & Exp. Corporation | New Dragon Industrial Co., Ltd | Zibo Panxin Pharmaceutical Co., Ltd. | Discovery Fine Chemicals Limited | Unispec Chemicals Co. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | All Right Chemical Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Jinan Great Chemical Co., Ltd. | Ningbo Hi-Tech Biochemicals Co., Ltd. | Hubei MaxSource Chem Co., Ltd. | King Tang Chemical Group Industry Co., Ltd. | Watson International Ltd | BOC Sciences | Jinan Haohua Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Gihi Chemicals Co., Limited | Clearsynth Canada INC. | Nebula Chemicals Co, Ltd. | Haihang Industry Co., Ltd.

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