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2-Methoxyestradiol

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Formula: C19H26O3
CAS: 362-07-2
search Element: methoxyestradiol

Identification

Structural Formula
2-Methoxyestradiol
CAS:
362-07-2
EINECS:
Molecular Formula:
C19H26O3
MDL:
MFCD00010489
SMILES:
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
Synonym:
17β-2-methoxyestradiol ; 2-methoxyestradiol 98+% ; 2-methoxy-17-estradiol ; 2-methoxyestradiol ; 7-methoxyestradiol ; 2-hydroxyestradiol 2-methyl ether ; 2-methoxyoestradiol ; estradiol, 2-methoxy- (6ci) ; 2-me2 ; 2-methoxyestra-1,3,5(10)-triene-3,17b-diol ; 2-methoxy-17b-estradiol ; estra-1,3,5(10)-triene-3,17b-diol, 2-methoxy- (7ci,8ci) ; panzem ; nsc 659853


Description

2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. 2-Methoxyestradiol is formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. 2-Methoxyestradiol is a derivative of an oestrogenic steroidal hormone and has demonstrated: potent inhibition of endothelial cell proliferation and migration and inhibition of bFGF and VEGF-induced corneal neovascularization in mice. In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF mediated transcriptional activation of target genes without affecting the transcription of HIF-1α itself. 2-Methoxyestradiol has been shown to induce apoptosis through activation of the p53 pathway through either activation of p38 and NF-κB or JNK and AP-1 both leading to Bcl-2 phsophorylation. In addition the compound has also been observed to upregulate death receptor 5 and bind to tubulins.


Suppliers

Ambeed, Inc.
A200225
Shandong Ench Chemical Co.,Ltd
SECC5402700
Aea.ltd
A126252
Chemlyte Solutions
CS324972
CSNpharm, Inc.
CSN19253
Wanko Chemical Co., Ltd.
WC4321296
Sigma-Aldrich International GmbH
SI5761728
Finetech Industry Limited
FIL4501800
Pharmacore Co., Limited
PL4141242
CM Fine Chemicals
CFC3061224
Leap Chem Co., Ltd
LC324972
Santa Cruz Biotechnology, Inc.
201371
Dayang Chem (Hangzhou) Co.,Ltd.
DC5582232
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CAS equal suppliers

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Pharmaffiliates Analytics & Synthetics Pvt. Limited
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TCI Chemicals (India) Pvt. Ltd.
M2530
2-Methoxy-d3-17beta-estradiol
Santa Cruz Biotechnology, Inc.
sc-216236
Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17b)-
Angene International Limited
AGN-PC-0O9BSJ

Prices & Availability




Data is processed


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Properties for 2-Methoxyestradiol

Molecular Weight:
302.45 g·mol−1
Density:
1.178 g/cm3
Melting point:
188-190 °C
Boiling point:
464.4 °C at 760 mmHg
Flash point:
234.7 °C
Solubility:
DMSO: 10 mg/mL
Physical Description:
off-white solid
Transport Information:
UN 3077 9/PG 3
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Safety & Transport Information

Risk Codes:
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R45 - May cause cancer
R46 - May cause inheritable genetic damage
R48 - Danger of serious damage to health by prolonged exposure
R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R60 - May impair fertility
R61 - May cause harm to the unborn child
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
Hazard Symbols:
T, Xi, N
Hazard symbol T Hazard symbol N Hazard symbol Xi
Storage temperature :
-20°C
RID/ADR certification :
UN 3077 9 / PG 3
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Alternative Distributors of [2-Methoxyestradiol]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

GLSynthesis Inc. | Molekula GmbH | BUJNO Synthesis Sp z o.o. | Share Chemical Co., Ltd. | Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd. | BOC Sciences | All Right Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Zhongda Chemistry | Shaanxi TOP Pharm Chemical Co.,Ltd. | Gihi Chemicals Co., Limited | Wanko Chemical Co., Ltd.

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